News

As many in the hepatology community are aware, HCV Research UK has been operating for more than a decade, providing clinical data and biological samples from a national cohort to support research studies into HCV infection. In total, more than 100 applications for accessing data and samples have been approved, enabling unique insight into the characteristics of infection, pathogenesis and the mechanisms underlying treatment response.

With the advent of direct acting antivirals and the progress towards elimination, there are now few applications requesting access to the resources. In addition, the clinical database has not been updated for several years. As a consequence, the HCV Research UK Management Group has decided to close provision of data and samples by the end of this year. Therefore, we would urge anyone who may wish to use the clinical data and biological samples to lodge applications by the end of May 2024. The process for applying to access HCV Research UK resources can be found at www.hcvresearchuk.co.uk . We also suggest contacting either Will Irving (will.irving@nottingham.ac.uk) or John McLauchlan (john.mclauchlan@glasgow.ac.uk) in the first instance. This would allow sufficient time to process the applications, complete the necessary MTAs, prepare the clinical data and set aside any samples that would be needed for any research studies.

The Management Group wishes to express its gratitude to the clinical teams and HCV Research UK staff whose commitment and efforts enabled the creation of a national cohort. Finally, we will be forever grateful to the individuals living with the virus who generously provided their clinical data and samples to the benefit of studies that have deepened our knowledge of HCV infection.

HCV Research UK Management Group

Professor Will Irving (University of Nottingham)
Professor John McLauchlan (University of Glasgow)
Professor John Dillon (University of Dundee)
Professor Sharon Hutchinson (Glasgow Caledonian University

The British Liver Trust is looking for new Trustees to join their Board.

Their Trustees play a pivotal role in providing governance and guidance to ensure they are delivering for people with liver disease and liver cancer. They are involved in setting the strategic direction of the organisation, as well as holding the senior management team to account. The trustees work closely as a team with the senior management team of the charity, playing an active role advising and mentoring as required.

The British Liver Trust is a small charity with big ambitions. They want liver disease to have the same profile and awareness as the other big killer diseases such as heart disease, stroke, and cancer.

They are looking to recruit trustees to help the charity grow and develop to meet this challenge. At this time, they would particularly like:

• to recruit a clinician with specialist Hepatitis B knowledge, and
• to broaden the diversity of their Board, particularly ethnic diversity which they recognise as limited currently

The British Liver Trust is committed to improving equality, diversity, and inclusion across the organisation and to building a Board with a variety of backgrounds, skills and views, so that their leadership reflects the population at large and the communities they serve. They also welcome applications from people who have personal experience of liver disease. Please tell us if there may be any barriers to your engagement with us and we will actively work with you to remove these.

They currently have 4 Board meetings a year, usually virtually, Trustees may be asked to sit on a Board sub-committee relevant to their skill set and are invited to get involved in other ways from time to time.

If you have the skills, knowledge and experience required, please ask for a pack from helen.westhead@britishlivertrust.org.uk .

If you would like an informal chat with the British Liver Trust Chief Executive, Pamela Healy, please email Helen with your availability so that she can arrange this.

Applications close midnight on 14 February 2024.

www.britishlivertrust 

More information can be found in the Media Release here >  Download Pathway Improvement Project-Media Release-August 2nd 2023.pdf

After the original NCEPOD Report into the care of patients dying with alcohol-related liver disease (ArLD) published in 2013, a survey conducted by NCEPOD has re-evaluated the problems highlighted in the initial Report. This focused on the detection and management of alcohol dependent patients as well as those admitted with alcohol-related liver disease.

The survey Report – ‘Remeasuring the Units’ was published by NCEPOD on 15th December 2022 and highlights where there is further work to be done. It shows that the majority of hospitals still do not have Alcohol Care Teams, that the use of the BASL/BSG Care Bundle needs to be in routine use more widely, and that in over a quarter of Trusts patients with decompensated cirrhosis are not routinely under the care of a gastroenterologist or hepatologist.

For the full Report please click on the link > Here . 

On 27th October 2022 the British Liver Trust launched Liver Cancer UK in response to rising cases of liver cancer across the country.

Liver cancer is the fastest rising cause of cancer death in the UK. Over the past decade, liver cancer incidence rates have increased by almost half (45%) in the UK and the number of people dying from liver cancer has risen the fastest out of all the twenty most common types of cancer. There are now over 40% more deaths from liver cancer in both men and women than there were a decade ago (1&2).

The disease also has a high mortality rate. Every year over 6,000 people are diagnosed with liver cancer country-wide and just 13% of them will survive for five years or more. (3) Survival rates depend on several factors, including the stage of the disease when it is diagnosed.

Many patients with liver cancer will only be diagnosed after an emergency admission to hospital or an emergency GP referral after symptoms have become severe and the cancer is more advanced. (4) In England, 44.9% of liver cancers are diagnosed in an emergency setting, such as an A&E department (5).

Liver Cancer UK will provide much needed information and support for patients affected by this devastating cancer and provide a focus for action to address this escalating situation. It will aim to improve the lives and outcomes of people affected by liver cancer and, ultimately, reduce cases of the disease.

The British Liver Trust will continue to work towards a world free of all liver diseases in addition, and as part of, its commitment to tackle liver cancer. Liver cancer is most common in people who already have liver disease, especially if they have cirrhosis (damage and scarring) of the liver which is most often caused by viral hepatitis, alcohol or obesity (6).

Pamela Healy OBE, Chief Executive of British Liver Trust, said:
“Liver cancer patients have told us that they didn’t realise that the British Liver Trust was also here for liver cancer patients - they were often confused and worried and did not know where to turn for help. We’ve created new resources and a website with targeted information to make it easier for people to get the help they need. The new programme of activity is in response to the very worrying increase in cases across the UK. We’re also deeply concerned that survival rates for liver cancer remain so low. It’s a situation which needs to urgently change.

“Liver Cancer UK, as part of the British Liver Trust, will be dedicated to saving and improving the lives of people affected by liver cancer by raising awareness, providing support and campaigning for faster diagnosis and more research into treatments and cures.”

Fiona Bailey (age 48), a liver cancer patient from Hampshire, said:
“When I was diagnosed with liver cancer, aged 45, my husband and I weren’t sure where to turn for support. At the time, I didn’t know anybody who had gone through it apart from my father-in-law who was diagnosed ten years earlier. I was diagnosed in time for surgery although I do continue to live with the ‘worry’ that it could come back. It’s brilliant that the British Liver Trust is launching Liver Cancer UK to provide dedicated information and support to patients like me and to increase awareness of liver cancer to ensure more people are diagnosed earlier. When you’ve been through something like this you just want to help other people.”

As well as the rising cases, late diagnosis of liver cancer continues to be a problem. This is partly due to the population’s low awareness of the symptoms of the disease. In 2021, the Less Survivable Cancers Taskforce released data showing that only 5% of people in the UK were able to correctly identify all symptoms of liver cancer from a list presented to them.

Professor Stephen Ryder, Medical Advisor to the British Liver Trust and Consultant Hepatologist at NHS Nottingham University Hospital, added:

“Lack of awareness of primary liver cancer and its causes is a common problem in the UK.

“The causes of liver disease and HCC, the most common primary liver cancer, are similar and interlinked. The good news is that there are things you can do to reduce the risks. Maintaining a healthy weight, avoiding drinking alcohol excessively and protecting yourself against viral hepatitis are the best defences against both liver disease and liver cancer.

“People can also develop cancer of the liver and gallbladder without the associated risk factors and should be concerned if they have any symptoms that are persistent and not normal for them. If you’re experiencing symptoms such as loss of appetite, nausea, a swollen stomach or yellowing of your skin and/or eyes, please don’t ignore them - make an appointment with your doctor to get them checked out.”

Symptoms of liver cancer include unintentional weight loss, loss of appetite, feeling very full after eating, feeling and being sick, pain or swelling in your abdomen, jaundice (yellowing of your skin and the whites of your eyes), itchy skin, feeling very tired and weak, fever with shivers, vomiting blood, dark black tarry poo or dark urine. However, the majority of these symptoms do not occur until liver cancer is at an advanced stage, so the British Liver Trust is calling for all people who are diagnosed with cirrhosis and who are most at risk to be regularly screened for liver cancer.

Visit Liver Cancer UK to find out more.

1.Over the last decade, liver cancer incidence rates have increased by almost half (45%) in the UK. Rates in females have increased by almost two-fifths (38%), and rates in males have increased by almost half (46%) (2016-2018): https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/liver-cancer#heading-Zero 
2.Liver cancer has shown the fastest increase in mortality (within the current 20 most common UK causes of cancer death) over the past decade in the UK for both females and males. Liver cancer mortality rates have increased by 45% in females and 42% in males over the past decade in the UK. Reference: Cancer Research UK (2019). Cancer mortality for common cancers. [online]. Available at: https://www.cancerresearchuk.org/health-professional/cancer-statistics/mortality/common-cancers-compared (last accessed October 2022).
3.https://britishlivertrust.org.uk/liver-cancer-awareness-month/ 
4.The Emergency Presentation Route comprises different emergency pathways into secondary care, including A&E attendance, emergency GP referrals to an inpatient setting (non–two week wait referrals) and emergency admissions to either an inpatient or outpatient setting.
5. https://www.cancerdata.nhs.uk/emergencypresentations . Data compared for 2020 Q3. Percentages differ slightly when compared to the National Cancer Registration Dataset due to diagnostic coding - this data is only currently available for 2006-2016.
6.https://britishlivertrust.org.uk/information-and-support/living-with-a-liver-condition/liver-conditions/liver-cancer-hcc/